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KMID : 0043319980210060734
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Archives of Pharmacal Research
1998 Volume.21 No. 6 p.734 ~ p.737
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Screening and isolation of Antibiotic Resistance Inhibitors from Herb Materials IV- Resistance Inhibitors from Anetheum graveolens and Acorns gramineus
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Kim Hye-Kyung
Moon Kyung-Ho
Ryu Shi-Yong
Moon Dong-Cheul
Lee Chung-Gyu
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Abstract
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The hexane fractions from methanolic extracts of Anetheum graveolens L. (Umbelliferae) and Acorus gramineus Soland. (Araceae) revealed potent inhibitory activities against the resistance of multi-drug resistant Staphylococcus aureus SA2 when combined with ampicillin (Am) or chloramphenicol (Cm). As active principles, carvone and the liquid mixture containing carvone from Anetheum graveolens L. and a liquid mixture mainly consisting of benzoic acid phenyl-methyl ester (benzyl benzoate) from Acorus gramineus Soland. were identified. They showed resistance inhibition at the level of 20-50/ml when combined with 100 or /ml of Am or Cm, respectively.
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KEYWORD
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Anetheum graveolens, Acorus gramineus, Carvone, Benzyl benzoate, Antibiotics resistance inhibition, Staphylococcus aureus SA2
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